{"id":16535,"date":"2025-10-06T19:18:23","date_gmt":"2025-10-06T19:18:23","guid":{"rendered":"https:\/\/introlab.net\/prader-willi-sindrom-uzroci-simptomi-i-mogucnosti-lecenja\/"},"modified":"2025-10-08T19:13:36","modified_gmt":"2025-10-08T19:13:36","slug":"prader-willi-syndrome-causes-symptoms-and-treatment-options","status":"publish","type":"post","link":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/prader-willi-syndrome-causes-symptoms-and-treatment-options\/","title":{"rendered":"Prader Willi Syndrome: Causes, Symptoms, and Treatment Options"},"content":{"rendered":"<p>Prader Willi syndrome is a <em>rare genetic disorder that affects multiple body systems and causes physical, mental, and behavioral changes<\/em>. Individuals with this condition often experience difficulties with<strong> appetite control, growth, muscle tone, and development.<\/strong> Although it occurs infrequently\u2014estimated in one out of every 10,000 to 30,000 newborns\u2014accurate diagnosis and early treatment can significantly improve quality of life.<br \/>\n<!--more--><\/p>\n<h2>What Is Prader Willi Syndrome<\/h2>\n<p>Prader Willi syndrome (PWS) occurs due to a<strong> genetic error on chromosome 15<\/strong>, most often on the section<strong> inherited from the father.<\/strong> This error prevents the normal functioning of certain genes responsible for <em>growth, development, and hormone regulation.<\/em><\/p>\n<p>Because of this, children with PWS go through two characteristic phases:<\/p>\n<ul>\n<li><strong>In early childhood<\/strong>, there is low muscle tone (hypotonia), a weak sucking reflex, and feeding difficulties.<\/li>\n<li><strong>Later in childhood and adolescence<\/strong>, increased appetite, obesity, and issues with self-control and behavior typically develop.<\/li>\n<\/ul>\n<figure id=\"attachment_16525\" aria-describedby=\"caption-attachment-16525\" style=\"width: 770px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"wp-image-16525 size-full\" src=\"https:\/\/staging-introlab.dev-digitaldot.com\/wp-content\/uploads\/2025\/10\/pexels-kpauksh.jpg\" alt=\"A mother holding her child with Prader Willi syndrome.\" width=\"770\" height=\"350\" srcset=\"https:\/\/staging-introlab.dev-digitaldot.com\/wp-content\/uploads\/2025\/10\/pexels-kpauksh.jpg 770w, https:\/\/staging-introlab.dev-digitaldot.com\/wp-content\/uploads\/2025\/10\/pexels-kpauksh-300x136.jpg 300w, https:\/\/staging-introlab.dev-digitaldot.com\/wp-content\/uploads\/2025\/10\/pexels-kpauksh-768x349.jpg 768w\" sizes=\"(max-width: 770px) 100vw, 770px\" \/><figcaption id=\"caption-attachment-16525\" class=\"wp-caption-text\">Genetic changes on chromosome 15 cause Prader Willi syndrome.<\/figcaption><\/figure>\n<h2>Causes and Genetic Basis of Prader Willi Syndrome<\/h2>\n<p>Prader Willi syndrome is not inherited in the traditional sense; it usually occurs randomly as a <strong>result of a spontaneous genetic error on chromosome 15<\/strong>, specifically in the region 15q11\u201313. There are several mechanisms that can lead to this condition:<\/p>\n<ul>\n<li><strong>Deletion (loss of a segment of the father\u2019s copy of chromosome 15)<\/strong> \u2013 the most common cause, seen in about 74% of cases.<\/li>\n<li><strong>Maternal uniparental disomy (UPD)<\/strong> \u2013 the child inherits both copies of chromosome 15 from the mother and none from the father; this occurs in approximately 25% of cases.<\/li>\n<li><strong>Error in the genetic \u201cimprinting\u201d process<\/strong> \u2013 the genes are present but not properly activated, leading to a complete loss of functional PW genes.<\/li>\n<li><strong>Rare translocations or mutations in the imprinting control region<\/strong> \u2013 these can cause more severe forms of the syndrome and increase the risk of recurrence within the family.<\/li>\n<\/ul>\n<p>In normal development, the maternal copy of the genes in this region is naturally <strong>\u201csilenced,\u201d<\/strong> while the paternal copy is <strong>active and functional.<\/strong> When a deletion, disomy, or imprinting error occurs, the body is left without active PW genes &#8211; directly leading to the development of Prader Willi syndrome.<\/p>\n<h2>Risk of Recurrence and Inheritance<\/h2>\n<p>Most cases of Prader Willi syndrome occur spontaneously, meaning parents typically do not have an increased risk of having another child with the same condition. The average recurrence risk is<strong> less than 1%<\/strong> when the cause is a deletion or uniparental disomy.<\/p>\n<p>However, if a <strong>parental chromosomal translocation<\/strong> is present, the risk can rise to 25%, and in cases involving a mutation in the imprinting control region, it can reach up to 50%. Therefore, <a href=\"https:\/\/staging-introlab.dev-digitaldot.com\/en\/genetic-counseling\/\">genetic counseling<\/a> is recommended for couples who already have a child with PWS to assess individual risk and plan future pregnancies.<\/p>\n<h2>How to Recognize the Symptoms of Prader Willi Syndrome<\/h2>\n<p>Symptoms change with age and can vary greatly, but there are characteristic signs that help identify the disorder.<\/p>\n<p><strong>Symptoms of Prader Willi Syndrome in Newborns:<\/strong><\/p>\n<ul>\n<li>Low muscle tone \u2013 the baby appears \u201cfloppy\u201d and moves arms and legs with difficulty.<\/li>\n<li>Feeding problems and weak sucking reflex.<\/li>\n<li>Weak cry and low activity levels.<\/li>\n<li>Delayed development of reflexes and motor skills.<\/li>\n<\/ul>\n<p><strong>Childhood Symptoms:<\/strong><\/p>\n<ul>\n<li>Increased appetite and uncontrolled hunger (hyperphagia) \u2013 the child constantly eats and seeks food.<\/li>\n<li>Rapid weight gain and development of obesity.<\/li>\n<li>Short stature due to reduced growth hormone production.<\/li>\n<li>Typical physical features: prominent nasal bridge, high and narrow forehead, almond-shaped eyes, thin upper lip, small hands and feet, and lighter hair and skin compared to other family members.<\/li>\n<li>Stretch marks and fat accumulation, especially around the abdomen.<\/li>\n<\/ul>\n<p><strong>Symptoms of Prader Willi Syndrome in Adolescence and Adulthood:<\/strong><\/p>\n<ul>\n<li>Hypogonadism \u2013 reduced function of the sex glands, leading to delayed or incomplete puberty. Most adults with PWS are infertile.<\/li>\n<li><a href=\"https:\/\/staging-introlab.dev-digitaldot.com\/en\/how-physical-activity-helps-manage-type-2-diabetes\/\">Type 2 diabetes<\/a> and high blood pressure as consequences of obesity.<\/li>\n<li>Sleep apnea and breathing difficulties.<\/li>\n<li>Mood changes, stubbornness, and impulsivity, often accompanied by anxiety and obsessive-compulsive behavior.<\/li>\n<li>Mild intellectual disability and learning difficulties.<\/li>\n<\/ul>\n<figure id=\"attachment_16519\" aria-describedby=\"caption-attachment-16519\" style=\"width: 770px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"wp-image-16519 size-full\" src=\"https:\/\/staging-introlab.dev-digitaldot.com\/wp-content\/uploads\/2025\/10\/pexels-rdn-7.jpg\" alt=\"A mother with two children.\" width=\"770\" height=\"350\" srcset=\"https:\/\/staging-introlab.dev-digitaldot.com\/wp-content\/uploads\/2025\/10\/pexels-rdn-7.jpg 770w, https:\/\/staging-introlab.dev-digitaldot.com\/wp-content\/uploads\/2025\/10\/pexels-rdn-7-300x136.jpg 300w, https:\/\/staging-introlab.dev-digitaldot.com\/wp-content\/uploads\/2025\/10\/pexels-rdn-7-768x349.jpg 768w\" sizes=\"(max-width: 770px) 100vw, 770px\" \/><figcaption id=\"caption-attachment-16519\" class=\"wp-caption-text\">Proper recognition of early symptoms allows for faster diagnosis and more effective treatment.<\/figcaption><\/figure>\n<h2>Diagnosis and Genetic Testing<\/h2>\n<p>During pregnancy, it is possible to perform <strong>non-invasive prenatal tests (NIPT)<\/strong> that analyze free fetal DNA from a sample of the mother\u2019s blood. These tests use <a href=\"https:\/\/staging-introlab.dev-digitaldot.com\/en\/ngs\/\">NGS (Next Generation Sequencing) technology<\/a> &#8211; an advanced sequencing method that<strong> can detect even the smallest chromosomal abnormalities<\/strong>, including changes in the 15q11\u201313 region associated with Prader Willi syndrome.<\/p>\n<p>Such analyses can be done <strong>as early as the 10th week of pregnancy<\/strong>, are completely safe for both the mother and the baby and provide an early risk assessment. If the results show abnormalities, confirmatory diagnostic procedures\u2014most commonly <strong>amniocentesis or chorionic villus sampling (CVS) &#8211; <\/strong>are performed to precisely confirm the genetic status of the fetus.<\/p>\n<p>After birth, the diagnosis is based on clinical signs and genetic testing. The most frequently used method is <a href=\"https:\/\/staging-introlab.dev-digitaldot.com\/en\/ngs\/molecular-karyotype\/\">molecular karyotyping (array-CGH)<\/a>, which detects microdeletions and microduplications on chromosome 15. Early detection allows timely treatment planning and significantly improves the child\u2019s quality of life.<\/p>\n<h2>Treatment and Support for Individuals with Prader Willi Syndrome<\/h2>\n<p>Although <strong>there is no cure<\/strong> for Prader Willi syndrome, combined treatments and a multidisciplinary approach<em> can help manage symptoms and improve daily functioning.<\/em><\/p>\n<h3>Growth Hormone Therapy<\/h3>\n<p>One of the main forms of treatment is growth hormone therapy, which:<\/p>\n<ul>\n<li>Helps increase height and muscle mass.<\/li>\n<li>Improves physical fitness.<\/li>\n<li>May also have a positive effect on cognitive development.<\/li>\n<\/ul>\n<h3>Dietary Management<\/h3>\n<p>Since constant hunger is one of the main challenges, strict dietary control is essential:<\/p>\n<ul>\n<li>Careful planning of meals and calorie intake.<\/li>\n<li>Restricting unsupervised access to food.<\/li>\n<li>Increasing physical activity according to the individual\u2019s abilities.<\/li>\n<\/ul>\n<h3>Psychological and Educational Support<\/h3>\n<p>Due to emotional instability and frequent mood swings, the following therapies are beneficial:<\/p>\n<ul>\n<li><a href=\"https:\/\/www.apa.org\/ptsd-guideline\/patients-and-families\/cognitive-behavioral\" target=\"_blank\" rel=\"noopener\">Cognitive-behavioral therapy (CBT)<\/a> to develop self-control.<\/li>\n<li>Occupational therapy to strengthen motor and daily living skills.<\/li>\n<li>Educational programs tailored to intellectual abilities.<\/li>\n<\/ul>\n<h3>Medical Supervision<\/h3>\n<p><strong>Regular monitoring by multiple specialists is necessary<\/strong>, including an endocrinologist, nutritionist, psychologist, speech therapist, and physiotherapist. This multidisciplinary care ensures proper tracking of growth, hormone levels, behavior, and overall health.<\/p>\n<h2>Life with Prader Willi Syndrome<\/h2>\n<p>Caring for a person with this syndrome requires<em> long-term commitment from both the family and a team of professionals.<\/em> The main challenges include maintaining a healthy body weight and providing support with daily activities.<\/p>\n<p>With proper care, <em>individuals with PWS can attend school, develop social skills, and lead a relatively independent life.<\/em><\/p>\n<p>Family support plays a crucial role \u2014 through understanding, setting clear boundaries, and encouraging participation in social activities.<\/p>\n<figure id=\"attachment_16522\" aria-describedby=\"caption-attachment-16522\" style=\"width: 770px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"wp-image-16522 size-full\" src=\"https:\/\/staging-introlab.dev-digitaldot.com\/wp-content\/uploads\/2025\/10\/pexels-danikprihod.jpg\" alt=\"Parents lying next to their baby.\" width=\"770\" height=\"350\" srcset=\"https:\/\/staging-introlab.dev-digitaldot.com\/wp-content\/uploads\/2025\/10\/pexels-danikprihod.jpg 770w, https:\/\/staging-introlab.dev-digitaldot.com\/wp-content\/uploads\/2025\/10\/pexels-danikprihod-300x136.jpg 300w, https:\/\/staging-introlab.dev-digitaldot.com\/wp-content\/uploads\/2025\/10\/pexels-danikprihod-768x349.jpg 768w\" sizes=\"(max-width: 770px) 100vw, 770px\" \/><figcaption id=\"caption-attachment-16522\" class=\"wp-caption-text\">Support from family and professionals allows individuals with PWS to have a better quality of life.<\/figcaption><\/figure>\n<h2>Prognosis and Expected Outcomes<\/h2>\n<p>Thanks to advances in diagnosis and treatment, the life expectancy of individuals with Prader Willi syndrome has significantly increased. <strong>Most can reach adulthood<\/strong>, provided they receive ongoing medical and psychological support.<\/p>\n<p>The greatest risks are complications caused by obesity, such as <strong>diabetes, heart disease, and respiratory problems.<\/strong><\/p>\n<h2>Prader Willi Syndrome<\/h2>\n<p>Prader Willi syndrome is a <em>rare but well-defined genetic disorder that requires early diagnosis<\/em>, continuous care, and a team-based approach. With modern diagnostic methods, hormone therapy, proper nutrition, and psychological support, individuals with this syndrome can lead fulfilling and active lives.<\/p>\n<p>The key to success lies in understanding, patience, and support \u2014 both from the family and from professionals who guide each stage of development.<\/p>\n<p>If there is a suspicion of a genetic disorder such as Prader Willi syndrome, testing can provide clear answers. At <a href=\"https:\/\/staging-introlab.dev-digitaldot.com\/en\/\">IntroLab in Belgrade<\/a>, <strong>prenatal and postnatal genetic tests are available<\/strong> to help detect changes on chromosome 15 and confirm the diagnosis.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Prader Willi syndrome is a rare genetic disorder that affects multiple body systems and causes physical, mental, and behavioral changes. Individuals with this condition often experience difficulties with appetite control, growth, muscle tone, and development. Although it occurs infrequently\u2014estimated in one out of every 10,000 to 30,000 newborns\u2014accurate diagnosis and early treatment can significantly improve [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":16517,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[159],"tags":[],"class_list":["post-16535","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Prader Willi Syndrome: Causes, Symptoms, and Treatment Options | Blog | IntroLab Belgrade<\/title>\n<meta name=\"description\" content=\"Prader Willi syndrome is a rare genetic disorder affecting appetite, growth, and behavior. Learn about its causes and treatments.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/staging-introlab.dev-digitaldot.com\/en\/prader-willi-syndrome-causes-symptoms-and-treatment-options\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Prader Willi Syndrome: Causes, Symptoms, and Treatment Options | Blog | IntroLab Belgrade\" \/>\n<meta property=\"og:description\" content=\"Prader Willi syndrome is a rare genetic disorder affecting appetite, growth, and behavior. Learn about its causes and treatments.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/staging-introlab.dev-digitaldot.com\/en\/prader-willi-syndrome-causes-symptoms-and-treatment-options\/\" \/>\n<meta property=\"og:site_name\" content=\"Introlab Laboratorija Beograd\" \/>\n<meta property=\"article:published_time\" content=\"2025-10-06T19:18:23+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-10-08T19:13:36+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/staging-introlab.dev-digitaldot.com\/wp-content\/uploads\/2025\/10\/pexels-tima-miroshnichenko-6462758.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"800\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"introlab admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"introlab admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"8 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/staging-introlab.dev-digitaldot.com\/en\/prader-willi-syndrome-causes-symptoms-and-treatment-options\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/staging-introlab.dev-digitaldot.com\/en\/prader-willi-syndrome-causes-symptoms-and-treatment-options\/\"},\"author\":{\"name\":\"introlab admin\",\"@id\":\"https:\/\/staging-introlab.dev-digitaldot.com\/en\/#\/schema\/person\/f4d4e2f66aef2e2bd8c5fa34f4404a75\"},\"headline\":\"Prader Willi Syndrome: Causes, Symptoms, and Treatment Options\",\"datePublished\":\"2025-10-06T19:18:23+00:00\",\"dateModified\":\"2025-10-08T19:13:36+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/staging-introlab.dev-digitaldot.com\/en\/prader-willi-syndrome-causes-symptoms-and-treatment-options\/\"},\"wordCount\":1258,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/staging-introlab.dev-digitaldot.com\/en\/#organization\"},\"image\":{\"@id\":\"https:\/\/staging-introlab.dev-digitaldot.com\/en\/prader-willi-syndrome-causes-symptoms-and-treatment-options\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/staging-introlab.dev-digitaldot.com\/wp-content\/uploads\/2025\/10\/pexels-tima-miroshnichenko-6462758.jpg\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/staging-introlab.dev-digitaldot.com\/en\/prader-willi-syndrome-causes-symptoms-and-treatment-options\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/staging-introlab.dev-digitaldot.com\/en\/prader-willi-syndrome-causes-symptoms-and-treatment-options\/\",\"url\":\"https:\/\/staging-introlab.dev-digitaldot.com\/en\/prader-willi-syndrome-causes-symptoms-and-treatment-options\/\",\"name\":\"Prader Willi Syndrome: Causes, Symptoms, and Treatment Options | Blog | IntroLab Belgrade\",\"isPartOf\":{\"@id\":\"https:\/\/staging-introlab.dev-digitaldot.com\/en\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/staging-introlab.dev-digitaldot.com\/en\/prader-willi-syndrome-causes-symptoms-and-treatment-options\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/staging-introlab.dev-digitaldot.com\/en\/prader-willi-syndrome-causes-symptoms-and-treatment-options\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/staging-introlab.dev-digitaldot.com\/wp-content\/uploads\/2025\/10\/pexels-tima-miroshnichenko-6462758.jpg\",\"datePublished\":\"2025-10-06T19:18:23+00:00\",\"dateModified\":\"2025-10-08T19:13:36+00:00\",\"description\":\"Prader Willi syndrome is a rare genetic disorder affecting appetite, growth, and behavior. Learn about its causes and treatments.\",\"breadcrumb\":{\"@id\":\"https:\/\/staging-introlab.dev-digitaldot.com\/en\/prader-willi-syndrome-causes-symptoms-and-treatment-options\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/staging-introlab.dev-digitaldot.com\/en\/prader-willi-syndrome-causes-symptoms-and-treatment-options\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/staging-introlab.dev-digitaldot.com\/en\/prader-willi-syndrome-causes-symptoms-and-treatment-options\/#primaryimage\",\"url\":\"https:\/\/staging-introlab.dev-digitaldot.com\/wp-content\/uploads\/2025\/10\/pexels-tima-miroshnichenko-6462758.jpg\",\"contentUrl\":\"https:\/\/staging-introlab.dev-digitaldot.com\/wp-content\/uploads\/2025\/10\/pexels-tima-miroshnichenko-6462758.jpg\",\"width\":1200,\"height\":800,\"caption\":\"Parents looking at their baby\u2019s ultrasound.\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/staging-introlab.dev-digitaldot.com\/en\/prader-willi-syndrome-causes-symptoms-and-treatment-options\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/staging-introlab.dev-digitaldot.com\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Prader Willi Syndrome: Causes, Symptoms, and Treatment Options\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/staging-introlab.dev-digitaldot.com\/en\/#website\",\"url\":\"https:\/\/staging-introlab.dev-digitaldot.com\/en\/\",\"name\":\"Introlab Laboratorija Beograd\",\"description\":\"Dijagnosti\u010dke Analize Krvi\",\"publisher\":{\"@id\":\"https:\/\/staging-introlab.dev-digitaldot.com\/en\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/staging-introlab.dev-digitaldot.com\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/staging-introlab.dev-digitaldot.com\/en\/#organization\",\"name\":\"Introlab Laboratorija Beograd\",\"url\":\"https:\/\/staging-introlab.dev-digitaldot.com\/en\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/staging-introlab.dev-digitaldot.com\/en\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/staging-introlab.dev-digitaldot.com\/wp-content\/uploads\/2023\/05\/introlablogo-ai.svg\",\"contentUrl\":\"https:\/\/staging-introlab.dev-digitaldot.com\/wp-content\/uploads\/2023\/05\/introlablogo-ai.svg\",\"caption\":\"Introlab Laboratorija Beograd\"},\"image\":{\"@id\":\"https:\/\/staging-introlab.dev-digitaldot.com\/en\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/staging-introlab.dev-digitaldot.com\/en\/#\/schema\/person\/f4d4e2f66aef2e2bd8c5fa34f4404a75\",\"name\":\"introlab admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/staging-introlab.dev-digitaldot.com\/en\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/35f074e779e78711c0945427d83940cde1ba146ab9fb782c93a29aae4cc10c0c?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/35f074e779e78711c0945427d83940cde1ba146ab9fb782c93a29aae4cc10c0c?s=96&d=mm&r=g\",\"caption\":\"introlab admin\"},\"sameAs\":[\"https:\/\/staging-introlab.dev-digitaldot.com\"],\"url\":\"https:\/\/staging-introlab.dev-digitaldot.com\/en\/author\/introlab-admin\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Prader Willi Syndrome: Causes, Symptoms, and Treatment Options | Blog | IntroLab Belgrade","description":"Prader Willi syndrome is a rare genetic disorder affecting appetite, growth, and behavior. Learn about its causes and treatments.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/prader-willi-syndrome-causes-symptoms-and-treatment-options\/","og_locale":"en_US","og_type":"article","og_title":"Prader Willi Syndrome: Causes, Symptoms, and Treatment Options | Blog | IntroLab Belgrade","og_description":"Prader Willi syndrome is a rare genetic disorder affecting appetite, growth, and behavior. Learn about its causes and treatments.","og_url":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/prader-willi-syndrome-causes-symptoms-and-treatment-options\/","og_site_name":"Introlab Laboratorija Beograd","article_published_time":"2025-10-06T19:18:23+00:00","article_modified_time":"2025-10-08T19:13:36+00:00","og_image":[{"width":1200,"height":800,"url":"https:\/\/staging-introlab.dev-digitaldot.com\/wp-content\/uploads\/2025\/10\/pexels-tima-miroshnichenko-6462758.jpg","type":"image\/jpeg"}],"author":"introlab admin","twitter_card":"summary_large_image","twitter_misc":{"Written by":"introlab admin","Est. reading time":"8 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/prader-willi-syndrome-causes-symptoms-and-treatment-options\/#article","isPartOf":{"@id":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/prader-willi-syndrome-causes-symptoms-and-treatment-options\/"},"author":{"name":"introlab admin","@id":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/#\/schema\/person\/f4d4e2f66aef2e2bd8c5fa34f4404a75"},"headline":"Prader Willi Syndrome: Causes, Symptoms, and Treatment Options","datePublished":"2025-10-06T19:18:23+00:00","dateModified":"2025-10-08T19:13:36+00:00","mainEntityOfPage":{"@id":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/prader-willi-syndrome-causes-symptoms-and-treatment-options\/"},"wordCount":1258,"commentCount":0,"publisher":{"@id":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/#organization"},"image":{"@id":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/prader-willi-syndrome-causes-symptoms-and-treatment-options\/#primaryimage"},"thumbnailUrl":"https:\/\/staging-introlab.dev-digitaldot.com\/wp-content\/uploads\/2025\/10\/pexels-tima-miroshnichenko-6462758.jpg","inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/staging-introlab.dev-digitaldot.com\/en\/prader-willi-syndrome-causes-symptoms-and-treatment-options\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/prader-willi-syndrome-causes-symptoms-and-treatment-options\/","url":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/prader-willi-syndrome-causes-symptoms-and-treatment-options\/","name":"Prader Willi Syndrome: Causes, Symptoms, and Treatment Options | Blog | IntroLab Belgrade","isPartOf":{"@id":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/prader-willi-syndrome-causes-symptoms-and-treatment-options\/#primaryimage"},"image":{"@id":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/prader-willi-syndrome-causes-symptoms-and-treatment-options\/#primaryimage"},"thumbnailUrl":"https:\/\/staging-introlab.dev-digitaldot.com\/wp-content\/uploads\/2025\/10\/pexels-tima-miroshnichenko-6462758.jpg","datePublished":"2025-10-06T19:18:23+00:00","dateModified":"2025-10-08T19:13:36+00:00","description":"Prader Willi syndrome is a rare genetic disorder affecting appetite, growth, and behavior. Learn about its causes and treatments.","breadcrumb":{"@id":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/prader-willi-syndrome-causes-symptoms-and-treatment-options\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/staging-introlab.dev-digitaldot.com\/en\/prader-willi-syndrome-causes-symptoms-and-treatment-options\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/prader-willi-syndrome-causes-symptoms-and-treatment-options\/#primaryimage","url":"https:\/\/staging-introlab.dev-digitaldot.com\/wp-content\/uploads\/2025\/10\/pexels-tima-miroshnichenko-6462758.jpg","contentUrl":"https:\/\/staging-introlab.dev-digitaldot.com\/wp-content\/uploads\/2025\/10\/pexels-tima-miroshnichenko-6462758.jpg","width":1200,"height":800,"caption":"Parents looking at their baby\u2019s ultrasound."},{"@type":"BreadcrumbList","@id":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/prader-willi-syndrome-causes-symptoms-and-treatment-options\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/"},{"@type":"ListItem","position":2,"name":"Prader Willi Syndrome: Causes, Symptoms, and Treatment Options"}]},{"@type":"WebSite","@id":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/#website","url":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/","name":"Introlab Laboratorija Beograd","description":"Dijagnosti\u010dke Analize Krvi","publisher":{"@id":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/#organization","name":"Introlab Laboratorija Beograd","url":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/#\/schema\/logo\/image\/","url":"https:\/\/staging-introlab.dev-digitaldot.com\/wp-content\/uploads\/2023\/05\/introlablogo-ai.svg","contentUrl":"https:\/\/staging-introlab.dev-digitaldot.com\/wp-content\/uploads\/2023\/05\/introlablogo-ai.svg","caption":"Introlab Laboratorija Beograd"},"image":{"@id":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/#\/schema\/person\/f4d4e2f66aef2e2bd8c5fa34f4404a75","name":"introlab admin","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/35f074e779e78711c0945427d83940cde1ba146ab9fb782c93a29aae4cc10c0c?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/35f074e779e78711c0945427d83940cde1ba146ab9fb782c93a29aae4cc10c0c?s=96&d=mm&r=g","caption":"introlab admin"},"sameAs":["https:\/\/staging-introlab.dev-digitaldot.com"],"url":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/author\/introlab-admin\/"}]}},"jetpack_featured_media_url":"https:\/\/staging-introlab.dev-digitaldot.com\/wp-content\/uploads\/2025\/10\/pexels-tima-miroshnichenko-6462758.jpg","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/wp-json\/wp\/v2\/posts\/16535","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/wp-json\/wp\/v2\/comments?post=16535"}],"version-history":[{"count":2,"href":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/wp-json\/wp\/v2\/posts\/16535\/revisions"}],"predecessor-version":[{"id":16537,"href":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/wp-json\/wp\/v2\/posts\/16535\/revisions\/16537"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/wp-json\/wp\/v2\/media\/16517"}],"wp:attachment":[{"href":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/wp-json\/wp\/v2\/media?parent=16535"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/wp-json\/wp\/v2\/categories?post=16535"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/wp-json\/wp\/v2\/tags?post=16535"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}