{"id":12988,"date":"2023-08-25T04:22:06","date_gmt":"2023-08-25T04:22:06","guid":{"rendered":"https:\/\/introlab.net\/?page_id=12988"},"modified":"2026-01-22T10:03:31","modified_gmt":"2026-01-22T10:03:31","slug":"scl-70-ab","status":"publish","type":"page","link":"https:\/\/staging-introlab.dev-digitaldot.com\/en\/scl-70-ab\/","title":{"rendered":"SCL 70 Ab"},"content":{"rendered":"<p>The SCL 70 Ab analysis is a specific <em>type of blood immunological test used to detect the presence of autoantibodies known as SCL 70.<\/em> These antibodies are often associated with systemic sclerosis, a chronic rheumatic disease that can affect various organs in the body.<!--more--><\/p>\n<h2>What is the SCL 70 Ab analysis?<\/h2>\n<p>This analysis detects the presence of SCL 70 autoantibodies in the blood. <strong>SCL 70 is a specific protein that may be present in individuals with systemic sclerosis,<\/strong> particularly those with a more progressive form of the disease.<\/p>\n<h2>Why is the analysis done?<\/h2>\n<p>The analysis is most commonly used to diagnose systemic sclerosis, <em>especially in patients who show symptoms of Raynaud&#8217;s syndrome.<\/em> It can also help differentiate this condition from other autoimmune diseases.<\/p>\n<h3>What is Raynaud&#8217;s syndrome?<\/h3>\n<p>Raynaud&#8217;s syndrome, or Raynaud&#8217;s disease, is a <strong>condition characterized by an excessive sensitivity to cold.<\/strong> When individuals with this syndrome are exposed to cold or stress, the blood vessels in the fingers of the hands or feet constrict, leading to reduced blood flow.<\/p>\n<p>Symptoms of Raynaud&#8217;s syndrome include:<\/p>\n<ul>\n<li><strong>Change in color of the fingers on the hands and feet<\/strong> (first white, then blue, then red).<\/li>\n<li><strong>The feeling of coldness or numbness in the affected areas.<\/strong><\/li>\n<li><strong>Tingling or stinging when blood flow is restored.<\/strong><\/li>\n<li><strong>Pain or discomfort in the affected fingers or toes.<\/strong><\/li>\n<\/ul>\n<p>These symptoms usually last a few minutes to several hours. <em>Reduced blood flow can lead to tissue damage or finger ulcers<\/em> in severe cases.<\/p>\n<p>There are two types of Raynaud&#8217;s syndrome: <strong>primary and secondary.<\/strong><\/p>\n<p>Primary Raynaud&#8217;s syndrome is the most common and occurs without connection to another disease. On the other hand, <em>secondary Raynaud&#8217;s syndrome is associated with other diseases, especially connective tissue diseases.<\/em><\/p>\n<h3>What sample is analyzed?<\/h3>\n<p>A blood sample taken from a vein is needed for the analysis.<\/p>\n<h2>How are the results interpreted?<\/h2>\n<p>SCL 70 antibodies in the blood may indicate systemic sclerosis, typically Raynaud&#8217;s syndrome. However, it is important to note that some patients with systemic sclerosis may not have these antibodies, while some people who have antibodies may not have the disease.<\/p>\n<h2>Analysis Specifics<\/h2>\n<ul>\n<li>Detection method: ELISA<\/li>\n<li>Sample stability: 2-8\u02daC for 14 days<\/li>\n<li>Minimum volume: 0.5ml<\/li>\n<\/ul>\n<h2>Related Analyses<\/h2>\n<p>Individuals suspected of having systemic sclerosis or Raynaud&#8217;s syndrome often undergo a series of diagnostic tests to confirm or exclude the diagnosis. In addition to the SCL 70 Ab analysis, which is specific for systemic sclerosis, several other tests can be recommended:<\/p>\n<ul>\n<li><strong><a href=\"https:\/\/staging-introlab.dev-digitaldot.com\/en\/ana-antinuclear-antibodies\/\">ANA test<\/a> (Antinuclear antibodies):<\/strong> This test detects the presence of antibodies that attack the cell nucleus. A positive ANA test may indicate an autoimmune disease but is not specific only to systemic sclerosis.<\/li>\n<li><strong>Centromere antibody test:<\/strong> These antibodies are often present in individuals with a limited form of systemic sclerosis.<\/li>\n<li>RNA polymerase III antibody test: These antibodies are often associated with the diffuse form of systemic sclerosis and an increased risk of renal crisis.<\/li>\n<li><strong>Capillaroscopy:<\/strong> This non-invasive technique uses a microscope to examine blood vessels under the nails. Individuals with systemic sclerosis often have specific changes in these blood vessels.<\/li>\n<li><strong>Duplex ultrasonography:<\/strong> This method uses ultrasonic waves to visualize blood vessels and can help assess blood flow and any abnormalities in blood vessels.<\/li>\n<li><strong>Skin biopsy:<\/strong> Taking a small skin sample can help confirm the diagnosis of systemic sclerosis, especially if there are typical changes in collagen and other skin structures.<\/li>\n<\/ul>\n<p>If you suspect Raynaud&#8217;s syndrome or systemic sclerosis, it is important to consult with a rheumatologist or another specialist who can recommend appropriate diagnostic tests and treatments.<\/p>\n<h2>Where can the analysis be done?<\/h2>\n<p>The SCL 70 Ab analysis can be done at the private laboratory in Belgrade, <a href=\"https:\/\/staging-introlab.dev-digitaldot.com\/en\/\">IntroLab<\/a>. Our laboratory provides professional and diverse laboratory diagnostics to all who need it.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The SCL 70 Ab analysis is a specific type of blood immunological test used to detect the presence of autoantibodies known as SCL 70. These antibodies are often associated with systemic sclerosis, a chronic rheumatic disease that can affect various organs in the body.<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-biohemiska.php","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[205],"tags":[],"class_list":["post-12988","page","type-page","status-publish","hentry","category-immunology"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>SCL 70 Ab | IntroLab Belgrade<\/title>\n<meta name=\"description\" content=\"The SCL 70 At analysis is available at our laboratory, IntroLab, in Belgrade. 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