TBG

Laboratory IntroLab in Belgrade is dedicated to providing accurate, fast, and reliable analyses that enable deeper insights into these processes. One of the analyses we offer is the TBG analysis, a key test for assessing thyroid gland status.

What is TBG?

TBG (Thyroxine-binding globulin) is a protein produced by our liver, which binds to thyroid hormones – thyroxine (T4) and triiodothyronine (T3) – and transports them to our cells through the bloodstream. These hormones are crucial for various bodily functions, including metabolism, growth, and development. As a ‘reservoir’ for these hormones, TBG ensures their gradual release into the bloodstream as needed, helping to maintain optimal hormonal balance. Understanding the role and function of TBG is essential for comprehending how our body uses thyroid hormones.

Why is this analysis important?

This analysis allows for the assessment of TBG levels in the blood, which can be useful in diagnosing and monitoring thyroid gland conditions. Increased or decreased TBG levels can indicate certain conditions and disorders that may affect thyroid function and overall health.

When is it necessary to perform this test?

TBG analysis is most often recommended when there are symptoms or signs that may indicate a thyroid function disorder. Also, this test may be recommended to monitor the effects of therapy in patients with diagnosed thyroid disorders.

Elevated and reduced levels

Changes in TBG levels can indicate various conditions. Elevated levels may be associated with:

• pregnancy
• use of estrogen
• genetic disorders

Symptoms associated with elevated levels may include fatigue, increased sensitivity to cold, dry skin, hair loss, slow metabolism, and depression, which are typical symptoms of hypothyroidism.

Reduced levels may indicate conditions such as:

• hypoproteinemia
• diseases leading to reduced protein production
• use of androgens

When levels are low, there may be an increase in free thyroid hormones, which can result in symptoms of hyperthyroidism. This can include weight loss without a change in diet, increased heart rate, increased sensitivity to heat, nervousness, tremor, or insomnia.

Specifics of the analysis

The TBG analysis is just one of a series of tests that can be used to assess thyroid gland function. This analysis is often used in combination with measuring thyroid hormone levels (T3 and T4), as well as the TSH (thyroid-stimulating hormone) test.