HLA B27 typing

HLA B27 typing is a genetic analysis that plays a crucial role in detecting the presence of the HLA B27 gene. This analysis provides important information about the genetic factor associated with spondyloarthritis, a group of inflammatory diseases affecting the joints and spinal cord. The genetics laboratory in Belgrade, IntroLab, is available for this analysis.

Why is HLA B27 typing important?

HLA B27 typing is essential for diagnosing spondyloarthritis. Identifying the presence of the HLA B27 gene offers critical insights for accurate diagnosis and planning appropriate treatment. A positive result from the HLA B27 typing can assist in the differential diagnosis between various forms of spondyloarthritis and guide treatment according to the individual needs of the patient.

When is this analysis indicated?

HLA B27 typing is indicated in cases of suspected spondyloarthritis, especially in patients who exhibit symptoms such as chronic back pain, limited joint mobility, eye or skin inflammation, and a history of conditions associated with spondyloarthritis. A doctor may recommend this analysis to confirm the diagnosis and facilitate appropriate treatment.

How is testing conducted?

This genetic blood analysis is performed from a sample of the patient’s DNA. The sample can be collected through a blood draw or saliva sample. After collection, laboratory experts at IntroLab will analyze the DNA to identify the presence or absence of the HLA B27 gene.

Interpreting results and specifics of the analysis

Results from HLA B27 typing can be positive (presence of the HLA B27 gene) or negative (absence of the HLA B27 gene). A positive result indicates an increased genetic risk for spondyloarthritis. It is important to note that the presence of the HLA B27 gene does not automatically mean that the disease will develop; it merely increases the risk. The results should be interpreted by a qualified physician who will consider the patient’s clinical picture and other relevant factors.