AZF Y microdeletions

The AZF microdeletion analysis of 15 loci is a genetic test identifying the presence or absence of microdeletions on the Y chromosome associated with male infertility. This analysis focuses on 15 specific loci on the Y chromosome, known as the AZF (Azoospermia Factor) regions. Identifying microdeletions in these regions helps diagnose certain causes of male infertility. The IntroLab genetic laboratory in Belgrade straightforwardly offers this test, delivering results in record time.

Why is the AZF microdeletion analysis important?

This genetic test is highly significant because it provides critical insights into the genetic causes of male infertility. Detecting microdeletions in the AZF regions helps understand potential genetic barriers to normal spermatogenesis (forming mature sperm cells). These results can assist in making accurate diagnoses, planning further treatments, and offering genetic counseling.

When is this test recommended?

The AZF microdeletion test is recommended for men facing unexplained infertility or a reduced sperm count in the ejaculate. It is particularly useful in cases of azoospermia (absence of sperm in the ejaculate) or severe oligozoospermia (a significantly low sperm count). Early identification of microdeletions in the AZF regions allows for quick intervention and possible alternative reproductive methods.

How is it performed?

The AZF microdeletion analysis of 15 loci is performed using a DNA sample from the patient. The sample can be collected via blood or saliva. After collecting the sample, laboratory experts isolate the DNA and analyze for the presence or absence of microdeletions in the 15 specific loci on the Y chromosome.

Interpretation of results and specifics of the analysis

The results of the AZF microdeletion analysis can be either positive (presence of microdeletions) or negative (absence of microdeletions). The presence of microdeletions in certain loci may indicate potential genetic barriers to normal spermatogenesis.