SCL 70 Ab

The SCL 70 Ab analysis is a specific type of blood immunological test used to detect the presence of autoantibodies known as SCL 70. These antibodies are often associated with systemic sclerosis, a chronic rheumatic disease that can affect various organs in the body.

What is the SCL 70 Ab analysis?

This analysis detects the presence of SCL 70 autoantibodies in the blood. SCL 70 is a specific protein that may be present in individuals with systemic sclerosis, particularly those with a more progressive form of the disease.

Why is the analysis done?

The analysis is most commonly used to diagnose systemic sclerosis, especially in patients who show symptoms of Raynaud’s syndrome. It can also help differentiate this condition from other autoimmune diseases.

What is Raynaud’s syndrome?

Raynaud’s syndrome, or Raynaud’s disease, is a condition characterized by an excessive sensitivity to cold. When individuals with this syndrome are exposed to cold or stress, the blood vessels in the fingers of the hands or feet constrict, leading to reduced blood flow.

Symptoms of Raynaud’s syndrome include:

• Change in color of the fingers on the hands and feet (first white, then blue, then red).
• The feeling of coldness or numbness in the affected areas.
• Tingling or stinging when blood flow is restored.
• Pain or discomfort in the affected fingers or toes.

These symptoms usually last a few minutes to several hours. Reduced blood flow can lead to tissue damage or finger ulcers in severe cases.

There are two types of Raynaud’s syndrome: primary and secondary.

Primary Raynaud’s syndrome is the most common and occurs without connection to another disease. On the other hand, secondary Raynaud’s syndrome is associated with other diseases, especially connective tissue diseases.

What sample is analyzed?

A blood sample taken from a vein is needed for the analysis.

How are the results interpreted?

SCL 70 antibodies in the blood may indicate systemic sclerosis, typically Raynaud’s syndrome. However, it is important to note that some patients with systemic sclerosis may not have these antibodies, while some people who have antibodies may not have the disease.

Analysis Specifics

• Detection method: ELISA
• Sample stability: 2-8˚C for 14 days
• Minimum volume: 0.5ml

Related Analyses

Individuals suspected of having systemic sclerosis or Raynaud’s syndrome often undergo a series of diagnostic tests to confirm or exclude the diagnosis. In addition to the SCL 70 Ab analysis, which is specific for systemic sclerosis, several other tests can be recommended:

• ANA test (Antinuclear antibodies): This test detects the presence of antibodies that attack the cell nucleus. A positive ANA test may indicate an autoimmune disease but is not specific only to systemic sclerosis.
• Centromere antibody test: These antibodies are often present in individuals with a limited form of systemic sclerosis.
• RNA polymerase III antibody test: These antibodies are often associated with the diffuse form of systemic sclerosis and an increased risk of renal crisis.
• Capillaroscopy: This non-invasive technique uses a microscope to examine blood vessels under the nails. Individuals with systemic sclerosis often have specific changes in these blood vessels.
• Duplex ultrasonography: This method uses ultrasonic waves to visualize blood vessels and can help assess blood flow and any abnormalities in blood vessels.
• Skin biopsy: Taking a small skin sample can help confirm the diagnosis of systemic sclerosis, especially if there are typical changes in collagen and other skin structures.

If you suspect Raynaud’s syndrome or systemic sclerosis, it is important to consult with a rheumatologist or another specialist who can recommend appropriate diagnostic tests and treatments.

Where can the analysis be done?

The SCL 70 Ab analysis can be done at the private laboratory in Belgrade, IntroLab. Our laboratory provides professional and diverse laboratory diagnostics to all who need it.