Anti-Gliadin IgG

The anti-gliadin IgG test is a blood test that identifies the presence of specific antibodies (IgG) against gliadin, a protein in gluten. This test is vital for diagnosing and managing conditions associated with this protein. Beograd Laboratory, IntroLab, and its staff are available for this specialized immunological analysis, among other tests.

What is the clinical significance of this test?

The anti-gliadin IgG test is crucial for diagnosing celiac disease, a genetic autoimmune disorder where the immune system reacts to gluten, particularly the gliadin protein. This test measures levels of antibodies (IgA and IgG) that are elevated in individuals with celiac disease. These antibody levels generally decrease rapidly following effective treatment.

Indications for the anti-gliadin IgG test

Individuals with symptoms of celiac disease or gluten intolerance may be advised to undergo this test.

Symptoms of celiac disease

Celiac disease manifests through a range of symptoms, which can vary in severity. Common symptoms include:

• Chronic fatigue
• Abdominal pain
• Bloating and gas
• Diarrhea or constipation
• Skin rash
• Weight loss
• Anemia

How is the anti-gliadin IgG test performed?

The test involves taking a blood sample. After collection, the sample is analyzed in a laboratory using an ELISA (Enzyme-Linked Immunosorbent Assay). The color change observed during the test indicates the presence of gliadin antibodies in the blood.

Sample stability

Following blood collection, the sample should be stored at 2-8°C for up to 14 days. It can be kept at -20°C for up to 1 month for extended storage.

What happens after the test?

The results will show if there is an immune response to gliadin. A doctor may suggest further tests or dietary modifications depending on the findings.

Interpreting results

Normal results for the anti-gliadin IgG test are negative. Elevated levels may suggest celiac disease or gluten sensitivity.

Preventing celiac disease

Celiac disease has a genetic component, so it cannot be prevented. However, it can be managed effectively with a strict gluten-free diet, which alleviates symptoms and helps maintain a normal life.

Subtypes of the test

In addition to the anti-gliadin IgG test, there is also the anti-gliadin IgA test. Both tests detect antibodies to gliadin but differ in the type of antibody they measure (IgG or IgA).