17-ketosteroids

17-ketosteroids are products of the metabolism of steroid hormones. This urine analysis is used to assess the function of the adrenal glands and testes, as well as to diagnose certain types of tumors. Our laboratory in Belgrade, IntroLab, provides an analysis of 17-ketosteroids in urine, enabling you to obtain accurate and reliable results.

What are 17-ketosteroids?

17-ketosteroids are a group of substances formed during the breakdown of steroid hormones in the liver. These hormones include cortisol, testosterone, and estrogen. After they are broken down, 17-ketosteroids are excreted from the body through urine.

Why is the analysis of 17-ketosteroids in urine important?

The analysis of 17-ketosteroids in urine is important because it can help diagnose various medical conditions. Elevated levels of 17-ketosteroids may indicate problems with the adrenal glands or the presence of certain types of tumors. Conversely, decreased levels may indicate Addison’s disease or hypopituitarism.

How to prepare for the analysis?

For the analysis of 17-ketosteroids, it is necessary to collect urine over 24 hours. Before starting urine collection, you should consult with your doctor about all medications you are currently taking, as some medications can affect the test results. Also, you should avoid intense physical activity the day before and during urine collection.

Interpreting the results of the 17-ketosteroids urine analysis

The results of this biochemical urine analysis are interpreted based on reference values that are established based on the range of normal values in the general population. Accordingly, normal values are:

Men: 7 to 20 mg per 24 hours
Women: 5 to 15 mg per 24 hours

It is important to note that normal values may slightly vary among different laboratories. Also, some medications and conditions can affect the results, so it is important to inform your doctor about all medications you are taking before testing.

Elevated values

Elevated levels of 17-ketosteroids may indicate various medical conditions, including:

• Adrenal gland problems, such as a tumor or Cushing’s syndrome
• Hormonal imbalance in women (polycystic ovary syndrome)
• Ovarian cancer
• Testicular cancer
• Excessive activity of the thyroid gland
• Obesity
• Stress

Decreased values

Decreased levels of 17-ketosteroids may occur in:

• Insufficient hormone production by the adrenal glands (Addison’s disease)
• Kidney damage
• Insufficient hormone production by the pituitary gland (hypopituitarism)
• Removal of the testes (castration)